Totally Drug-resistant Tuberculosis

Not multi-drug-resistant (MDR) TB, but TOTALLY drug resistant:

The PD Hinduja hospital detected four people with total drug resistant (TDR) tuberculosis (TB), the first such cases in the country till November last year. In the last two months, eight others have been detected with TDR-TB…

Till November 2011, the hospital got four TB patients resistant to all first-line (Isoniazid, Rifampicin, Ethambutol, Pyrazinamide and Streptomycin) and second-line (Ofloxacin, Moxifloxacin, Kanamycin, Amikacin, Capreomycin, Para-aminosalicylic acid and Ethionamide) drugs.

“After thoroughly checking their prescriptions, we found that three of them had received erratic and unsupervised second-line drugs. They were often given in incorrect doses by multiple private practitioners to cure their multi-drug resistant (MDR) TB,” Dr Udwadia said. “The mortality rate of MDR, XDR and TDR-TB is 30%, 60% and 100% respectively.”

Further details about these cases in India here (and probably elsewhere).

Very worrying indeed.